Extra thick cushion protects calluses from painful shoe pressure & friction. DO NOT USE IF -You are Diabetic -You have poor blood circulation -On irritated skin or any area that is infected or reddened!! ***Each package has its own Expiration Date!! Please see all offers and read sellers comments to see expiration date of the ones offered.Removes calluses. Relieves pain by removing calluses.Wash affected area and dry thoroughly. Apply medicated disk with sticky side adhering to the skin & cover medicated disk with enclosed cushion. After 48 hours remove medicated disk & reapply. Can repeat procedure every 48 hours for up to 14 days.Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.